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Pipeline

Off-the-Shelf mRNA Cancer Immunotherapies Designed for Durability
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CryptiVaxTM

Epitopea is building a pipeline of first-in-class mRNA cancer immunotherapies that combine multiple, shared Cryptigens™ into a single, off-the-shelf modality capable of activating targeted, durable anti-tumor immunity.
Our lead program, CryptiVax™-1001, is advancing into clinical development for high-grade serous ovarian cancer (HGSOC). This immunotherapy incorporates validated, tumor-presented Cryptigens™ that are presented by the most prevalent HLA allotypes, thereby allowing coverage of the majority of HGSOC patients.

Beyond ovarian cancer, we are expanding our pipeline into other indications, each leveraging newly discovered Cryptigen™ repertoires.

Therapeutic Focus

Ovarian Cancer - Targeting a Critical Unmet Need
High-grade serous ovarian cancer (HGSOC) is one of the most lethal women’s cancers, with ~80% of cases diagnosed at advanced stages and the vast majority eventually recurring despite current standards of care therapies. Primary treatment in advanced setting is surgery and (neo)-adjuvant chemotherapy. Women with HRP+ / BRCA -wild-type (BRCAwt) tumors, which represent nearly half of the patient population, have limited treatment options following first-line therapy.

CryptiVax™-1001 is being developed as a frontline maintenance therapy for HRP+/BRCAwt patients for whom existing treatments provide limited benefit. By delivering multiple tumor-specific Cryptigens™ in a single immunotherapy, CryptiVax™-1001 is designed to enable durable remission and provide meaningful improvement in long-term patient outcomes.

Our vision is to offer women with ovarian cancer a therapy that delivers lasting remission, not temporary benefit, and to set a new standard for treatment durability in this devastating disease.

Revealing Novel Targets For Next Generation Immunotherapies
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