Pierre began his career with the National Research Council of Canada as a protein chemistry Investigator. Between 2001 and 2004, he operated the Protein Analysis Department at Caprion Pharmaceuticals.

He then joined the Institute for Research in Immunology and Cancer (IRIC) of Université de Montréal where he operates the Proteomics Research Unit and the Center for Advanced Proteomics and Chemogenomics Analyses (CAPCA).

Pierre is also a Professor in the Department of Chemistry and an Accredited Member of the Department of Biochemistry of the Faculty of Medicine at Université de Montréal.